Lycanthropy is caused by a diseased portion of a totem spirit (almost always of predatory animals, but there was a case of butterfly lycanthropy, which delighted the children but terrifed the parents that their kids ended up in such a fragile state) breaking away from the primary totem, and with a passion for posessing material beings. A lycanthropic curse attaches to a tribe as opposed to indivduals, although the last afflicted individual is slightly more likely to become the next victim.
Giants

Cannot commune with totem spirits or ancestors, but can commune with thier own living kind.

Have always existed at the impossible borders/Limits.

Mate with Titans = ???

The Minose Terso (the ship-wrecked)
Flower Wars